朱熹和孟子解读舜之“怨慕”的不同逻辑

对于舜之“怨慕”,朱熹作出了不同于孟子的解读。这是基于心学、理学内在逻辑的不同。孟子作为私学之儒,和孔子一样,是主张士君子的阳刚人格的,并且从性向善的人性论出发,协调义与利、公与私的关系,而以君臣父子关系都属对待关系;依此,将舜之“怨慕”解读为舜对父母的既怨又慕。朱熹则作为官学之儒,以所谓“气质之性”协调理学先驱荀子的性向恶论,以二歧化思维把天地之性、天理绝对化,以公去私,视君臣父子关系则为下对上的绝对服从关系;依此解读,舜之“怨”只能是自怨。     

Accurate computation of single and product moments of order statistics under progressive censoring

An accurate procedure is proposed to calculate approximate moments of progressive order statistics in the context of statistical inference for lifetime models. The study analyses the performance of power series expansion to approximate the moments for location and scale distributions with high precision and smaller deviations with respect to the exact values. A comparative analysis between exact and approximate methods is shown using some tables and figures. The different approximations are applied in two situations. First, we consider the problem of computing the large sample variance–covariance matrix of maximum likelihood estimators. We also use the approximations to obtain progressively censored sampling plans for log-normal distributed data. These problems illustrate that the presented procedure is highly useful to compute the moments with precision for numerous censoring patterns and, in many cases, is the only valid method because the exact calculation may not be applicable.     

Inference and Decision Making for 21st-Century Drug Development and Approval

ABSTRACT

The cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making.     

客户集中度、市场环境与存货管理效率

客户处在供应链的下游,对企业存货的采购、生产和销售都会产生重要影响,而多变的市场环境也在无形当中影响着客户与企业之间的关系。从企业所处行业、地区产品市场和客户三个角度所带来的市场环境变化入手,采用2011—2017年我国沪深两市A股制造业上市公司的数据,实证分析客户集中度与企业存货管理效率之间的关系。研究发现:(1)客户集中度越高,企业存货管理效率越高；(2)产品市场竞争力度越强,客户集中度对企业存货管理效率的影响越大；(3)产品市场发育越好,客户集中度对企业存货管理效率的影响越大。进一步研究发现,当企业因客户生产经营原因导致需求发生较大变化时,客户集中度对企业存货管理效率的正向影响更加显著。研究结论表明,政府应当注重市场竞争力的提升和良好经营环境的建设,使得企业在维护客户关系的同时充分发挥客户集中度对企业存货管理效率的积极作用。     

美国中小学的体验式学习及启示

体验式学习的内涵随着时代的发展而逐渐丰富和深化，但无论其如何演变，直接经验和反思始终是体验式学习这一概念的内核。体验式学习理念渗透于美国教育文化之中。具体表现在：小学阶段的教育以学生的真实感知为基础，注重为学生提供真实体验的机会和激发学生的学习兴趣；中学尤其是高中阶段的教育以学生的真实体验为基础，注重为学生提供在新情境中检验所学知识的机会，注重学生知识、技能的内化吸收。美国中小学体验式学习的实施经验可为我国基础教育课程改革提供如下启示：（1）进一步树立和推广体验式学习理念；（2）创设学生进行真实体验的教学环境；（3）注重实施基于学生体验式学习的表现性评价。     

The importance of cross‐disciplinary scientific engagement in the development of quantitative procedures for aggregate safety assessments

Recent guidance on safety monitoring during drug development, issued by regulatory authorities in the United States and European Union, indicate a shift in focus towards aggregate safety monitoring and scientific evaluation of integrated safety data. The call for program‐level reviews of accumulating safety data, including from ongoing studies, provides an opportunity to leverage the scientific expertise and medical judgment of safety management teams with (a) a multidisciplinary approach, (b) quantitative frameworks to measure level of evidence, and (c) assessments that are product‐specific and driven by medical judgment. A multidisciplinary team, regularly reviewing aggregate safety data throughout the development program, is vital not only for early signal detection but also for generating a better understanding of the accumulating data and context needed for decreasing false alarms.     

On MLEs of the parameters of a modified Weibull distribution based on record values

The modified Weibull distribution can be used quite effectively to model complex data from mechanical engineering or survival analysis studies that posses a monotonic or a bathtub-shape hazard rate. In this paper, we study the MLEs of the parameters of a modified Weibull distribution model in the presence of upper kth record values. The existence and uniqueness of the MLEs are proven in this case. Real data analysis is performed for illustrative purposes.     

Women migrants in the global economy: a global overview (and regional perspectives)

ABSTRACT

Huge advances have been made in deepening and expanding our knowledge of gendered migration over the last decades in both theoretical and methodological terms. Empirically it is, however, still the case that North–South migration is at the basis of most theorisations, leaving the characteristics of South–South migration at the margins. In this paper we, therefore, shift the focus to intra- and trans-regional migration in a South–South context in exploring what this means for women migrants. While feminist scholars have highlighted care and the ways in which migration challenges social reproduction as an important issue, mainstream approaches continue to focus predominantly on the ‘productive’ lives of migrant workers. With migration theories still largely drawing on the experience of South–North migration, there continues to be relatively little understanding of South–South migration’s gender dynamics, despite the fact that many of the highly feminised, yet hyper-precarious, migration flows occur intra-regionally.